About CLARUS® Clarus® is a medicine taken by mouth to treat the most severe form of acne (nodular acne) that cannot be cleared up by any other acne treatments, including antibiotics. The active ingredient in Clarus® is called Isotretinoin, which is related to vitamin A. It belongs to a class of drugs called retinoids. Please be aware of significant warnings for people taking Clarus® , such as the high potential of birth defects and other health problems. Read this booklet carefully, as well as the ‘Information for the Consumer’ that comes with your prescription for Clarus® especially “What are the important warnings for females talking Clarus® ?” and “What special symptoms you must immediately tell your doctor about — Signs of mental health problems”. About  CLARUS® side effects Clarus® can cause serious side effects. Before starting Clarus® talk to your doctor about how bad your acne is, the possible benefits of  Clarus® and possible side effects. Your doctor will ask you to read and sign an Informed Consent Form. By signing the Informed Consent Form, you are signing that you understand some of the serious risks of Clarus®. For more information about side effects, please read the Information for the Consumer document that is given to you with your Clarus®  prescription. Note: You should read the Information for the Consumer every time you get a prescription or a refill for Clarus® because there may be new information. How to take CLARUS® Depending on your dosage of Clarus®, you’ll probably take it for at least 12 to 16 weeks. This is called a course of therapy. If you require a second course of therapy, it will start eight or more weeks after your first course is done. Read your prescription label carefully and take the exact amount of medicine prescribed by your doctor. The amount of Clarus® you should take has been chosen just for you. Your dose of Clarus® is based on your body weight, and your doctor may change your prescribed dose from time to time, so it’s important to check the label every time you fill your prescription. If you have any questions, call your doctor. The soft gelatin Clarus® capsule is easy to swallow. Do not chew or suck on the capsule. Swallow your Clarus® capsule whole with a full glass of liquid. It should be taken with food or just after a meal. If you forget to take your dose at mealtime, you can take it with a later meal that day, but don’t take more Clarus® in one day than your doctor has prescribed. The reddish brown capsule is the 10 mg size and the orange brown capsule is the 40 mg size. How to store CLARUS® You don’t need to refrigerate, Clarus® but it should be kept in its original package at a temperature of 15-30°C, protected from sunlight and heat. Be sure to keep Clarus® out of the reach of children.